A new Canadian study shows that Moderna’s COVID-19 shot may have between two and three times as many side effects related to the heart as Pfizer’s.
Within 21 days of getting their second shot, the rates of myocarditis and pericarditis were 35.6 and 22.9 per million doses, respectively, for Moderna, while they were 12.6 and 9.4 per million doses for Pfizer. The link between mRNA vaccines and heart problems was strongest in men and younger people who got the shots.
The authors of the study were quick to point out that heart inflammation was still pretty rare, and it seems that getting COVID-19 puts you at a higher risk of myocarditis or pericarditis than getting an mRNA vaccine.
The lead study author, Dr. Naveed Janjua, said in a news release from the American College of Cardiology that people who might get the vaccine should think about how most cases of myocarditis are mild and go away on their own. They should also think about the benefits of vaccination, how the Moderna vaccine is more effective against infection and hospitalization, and how the risk of myocarditis seems to be higher after COVID-19 infection than after mRNA vaccination.
“in whom minimizing risk of myocardial insult is crucial, these data give a strong argument to preferentially use the BNT162b2 [Pfizer] vaccine over mRNA-1273 [Moderna]” https://t.co/70nNikSsSv
— Amesh Adalja (@AmeshAA) November 9, 2022
The study’s authors also said that it should help people and policymakers decide between Pfizer and Moderna. They said that people who tend to get heart problems might do better to choose the first option.
Concerns have been raised about the link between mRNA vaccines and heart conditions by a number of medical groups and health professionals.
Some people have stopped recommending mRNA vaccines for young men because the risk-benefit ratio is not as good as it is for other groups.
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What Is Myocarditis Pfizer Rate?
The most cases of myocarditis were reported after the second dose of the BNT162b2 vaccine in 12–15-year-old girls (6.35 [95% CI, 4.05–9.96] per million doses of the BNT162b2 vaccine), in 16–17-year-old girls (10.98 [95% CI, 7.16–16.84] per million doses of the BNT162b2 vaccine), and in young adults.
Difference Between Moderna Risks vs Pfizer?
The risk ratios for Pfizer versus Moderna were 1.17 (95% CI: 1.03 to 1.28), 1.32 (95% CI: 1.16 to 1.49), 1.20 (95% CI: 1.05 to 1.32), and 1.16 (95% CI: 1.08 to 1.29) for ischemic stroke, heart attack, other blood-clotting events, and kidney injury, respectively.
Which Age Group Moderna Myocarditis Effect?
Most of these rare cases of myocarditis or pericarditis have happened in 16-year-old and older males within 7 days of getting their second dose of an mRNA COVID-19 vaccine (Pfizer-BioNTech and Moderna).